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1: Ariëns Award

De Ariëns lezing wordt jaarlijks georganiseerd door de Nederlandse Vereniging voor Farmacologie (NVF) ter nagedachtenis aan professor Ariëns, een van de grondleggers van het vakgebied farmacologie en professor aan de Universiteit van Nijmegen.


Sinds 1985 worden wetenschappers met een aanzienlijke staat van dienst binnen de farmacologie uitgenodigd om de Ariëns lezing in Lunteren te geven tijdens de jaarlijkse bijeenkomst van de NVF.  De NVF erkent het belang van het werk van professor Ariëns als grondlegger voor de farmacologie in Nederland en het belang van farmacologie als essentieel onderdeel bij de ontwikkeling van nieuwe geneesmiddelen.

In de attachments vindt u de lijst met voorgaande Ariens Awards winnaars.



Ariëns Award 2016 naar Prof. Susan Brain 


The board of the Dutch Pharmacological Society is honoured to announce Professor Susan Brain as recipient of the 2016 Ariens Award, an award in memory of Professor E.J. Ariens (1918-2002), and given annually as a recognition of outstanding scientific achievements in pharmacology.

Professor Susan Brain 

Cardiovascular Division and Pharmacology Dept, King’s College London, UK

Elucidating the roles of Transient Receptor Potential (TRP) Receptors and Sensory Nerves in Cardiovascular and Inflammatory Disease

Changes at the vascular and sensory nerve level in cardiovascular biology and inflammatory mechanisms are key in influencing the patho-physiology of many diseases. Research in our laboratory involves study of a range of murine models to determine the role of TRP receptors and how they can influence the sensory nerves that they are localised on. Current studies include: i) Understanding the potential of a sensory nerve-derived neuropeptide CGRP to mediate protective effects in a model of hypertension. ii)  Determining how TRPC5 channels are protective in models of arthritis and iii) Understanding how TRP channels, sensory nerves and neuropeptides are involve in the response to local and whole body thermoregulation in cold environments.


Susan Brain biography:

Susan gained her PhD in Pharmacology from the University of London. She then carried out postdoctoral posts studying inflammatory pathways and became a lecturer at King’s College London in 1989. She is now Professor of Pharmacology, Head of the Department of Pharmacology Education and Head of the Vascular Biology Section within the Cardiovascular Division. Her research is aimed at understanding how TRP receptors and sensory nerves are important as biological regulators. 

She is a member of the Society of Biology Education Committee.  From 2003-2009 she was Vice President of the British Pharmacology Society of Academic Affairs, involved in developing the BPS Advanced Diploma in Pharmacology. She has previously served on a range of academic and research committees for national and international bodies that include the British Inflammation Research Association (1997-2003), the European Neuropeptide Club (1999-2003; 2010-2013) and the Bayliss and Starling Committee 2003-2013. She has served on the Editorial Board of the British Journal of Pharmacology (1991-1995; 2000-2003), the Editorial Board for European Journal of Pharmacology (2003-2013) and is on the  board of Neuropeptides (2003-), and Molecular Neuroscience and the Journal of Inflammation (2003-). 

She is a Fellow of the British Pharmacological Society and a Fellow of the Society of Biology. She was recipient of the BPS Sandoz prize for her scientific contributions to pharmacology (1989), and won the Women in Inflammation Science Award presented at the World Inflammation Congress (2003), a King’s Supervisory Award (2008) and the BPS AstraZeneca prize for Women (2010).

She has sat on the MRC Industrial studentships panel (2007-2009) and the BBSRC Animal Sciences Grants Committee (2010-14); and is a Chair of the William Harvey Research Foundation Grants Committee (2010-14); Member of the MRC/BBSRC Healthy Ageing Grant Initiative Committee (2013) and Member of the Industrial/BPS Funding Consortium (2004-present). She is a member of the Research Excellence Framework (REF) panel for Biological Sciences (2014).
Research interests

Professor Brain has published over 180 research publications and been involved in the study of microcirculation since the early 1980s. Her early studies concentrated on the activity of vasoactive and pro-inflammatory arachidonate metabolites, in adipose tissue and skin, providing some of the first evidence for the presence of leukotriene B4 in psoriasis.

She first became interested in the sensory neuropeptide calcitonin gene-related peptide (CGRP) in 1985 (Brain et al., Nature 1985), when she discovered its potent vasodilator activity. This paper was ground-breaking and cited over 1750 times. It is now realised that CGRP antagonists are of benefit in migraine. Her studies of the cardiovascular role of CGRP have extended to investigate the role of this and related peptides and mechanisms in cardiovascular diseases and ageing.

Recent research into the role of non-selective cation channels transient receptor potential channels TRPV1 and TRPA1 and other channels, primarily localised to the sensory nerves, that release CGRP have revealed that these channels are involved in mediating inflammatory pain (relevant to arthritis); itch (relevant to skin conditions), as well as cardiovascular regulation and sepsis. This research links expertise in studying the peripheral microvasculature with sensory nerves and CGRP.